Ancef official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. HIGHLIGHTS OF PRESCRIBING INFORMATION. These highlights do not include all the information needed to use CEFAZOLIN injection safely and effectively. When culture and susceptibility information are available, they Prescribing Cefazolin for injection in the absence of a proven or strongly suspected bacterial .

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A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.

Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria.

May be used for surgical prophylaxis; if required metronidazole may be added to cover B. Cefazolin also known as cefazoline or cephazolin is a semi-synthetic first generation cephalosporin for parenteral administration.

Cefazolin has broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. In vitro tests demonstrate that the bactericidal action of cephalosporins results from inhibition of cell wall synthesis. By binding to specific penicillin-binding proteins PBPs located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis.

Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. Not absorbed from GI tract. Must be administered parenterally. Peak serum concentrations attained hours post intramuscular injection. Cefazolin is present in very low concentrations in the milk of nursing mothers. Cefazolin is excreted unchanged in the urine. The serum half-life is orescribing 1. Michael Bornstein, Sandra M.

Carone, “Method of preparing sterile essentially amorphous cefazolin for reconstitution for parenteral administration. Patent US, issued August, Drug created on June 30, Drug Interaction R -warfarin The risk or severity of bleeding can be increased when Cefazolin is combined with R -warfarin.

S -Warfarin The risk or severity of bleeding can be increased when Cefazolin is combined with S -Warfarin.

Abacavir Cefazolin may decrease the excretion rate of Abacavir which could result in a higher serum level. Abciximab The therapeutic efficacy of Abciximab can be decreased when used in combination with Cefazolin. Acarbose Cefazolin may decrease the excretion rate of Acarbose which could result in a higher serum level.

Cefazolin – DrugBank

Aceclofenac Cefazolin may decrease the excretion rate of Aceclofenac which could result in a higher serum level. Acemetacin The risk or severity of nephrotoxicity can be increased when Cefazolin is combined with Acemetacin. Acenocoumarol The risk or severity of bleeding can be increased when Cefazolin is combined with Acenocoumarol.

Acetaminophen Cefazolin may decrease the excretion rate of Acetaminophen which could result in a higher serum level. Acetazolamide The excretion of Cefazolin can be decreased when combined with Acetazolamide. Acetylsalicylic acid The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Cefazolin. Aclidinium Cefazolin may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Acrivastine Cefazolin may decrease the excretion rate of Acrivastine which could result in a higher serum level. Acyclovir Cefazolin may decrease the excretion rate of Acyclovir which could prescribinf in a higher serum level.

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Adefovir The risk or severity of nephrotoxicity can be increased when Cefazolin is combined with Adefovir. Adefovir Dipivoxil The risk or severity of nephrotoxicity can be increased when Adefovir Dipivoxil is combined with Cefazolin. Adenovirus type 7 vaccine live The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Cefazolin.

Albutrepenonacog alfa Cefazolin may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level. Alclofenac Cefazolin may decrease the excretion rate of Alclofenac which could result in a higher serum level.

Aldesleukin Cefazolin may decrease the excretion rate of Aldesleukin which could result in a higher serum level. Alendronic acid Prescribinf risk or severity of nephrotoxicity and hypocalcemia can be increased when Cefazolin is combined with Alendronic acid.

Allopurinol Cefazolin may decrease the excretion rate of Allopurinol which could result in a higher serum level. Allylestrenol Cefazolin may decrease the excretion rate of Allylestrenol which could result in a higher serum level. Almasilate Cefazolin may decrease the excretion rate of Almasilate which could result in a higher serum level.

Alminoprofen The risk or severity of nephrotoxicity can be increased when Cefazolin is combined with Alminoprofen. Almotriptan Cefazolin may decrease the excretion rate of Almotriptan which could result in a higher serum level.

Alogliptin Cefazolin may decrease the excretion rate of Alogliptin which could result in a higher serum level. Alprazolam Cefazolin may decrease the excretion rate of Alprazolam which could result in a higher serum level.

Alprostadil The excretion of Alprostadil can be decreased when combined with Cefazolin. Alteplase The therapeutic efficacy of Alteplase can be decreased when used in combination with Cefazolin.

Amantadine Cefazolin may decrease the excretion rate of Amantadine which could result in a higher serum level. Amediplase The therapeutic efficacy of Amediplase can be decreased when used in combination with Cefazolin. Amikacin The risk or severity of nephrotoxicity prescriing be increased when Amikacin is combined with Cefazolin.

Aminohippuric acid The excretion of Cefazolin can be decreased when combined with Aminohippuric acid. Aminophenazone The risk or severity of nephrotoxicity can be increased when Cefazolin prescribong combined with Aminophenazone. Amitriptyline Cefazolin may decrease ifnormation excretion rate of Amitriptyline which could result in a higher serum level.

Amlodipine Cefazolin may predcribing the excretion rate of Amlodipine which could result in a higher serum level. Ammonium chloride Cefazolin may decrease the excretion rate of Ammonium chloride which could result in a higher serum level. Amoxicillin Cefazolin may decrease the excretion rate of Amoxicillin which could result in a higher serum level.

Amphetamine Cefazolin may decrease the excretion rate of Amphetamine which could result in a higher serum level. Amphotericin B The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Cefazolin.

Ampicillin Cefazolin may decrease the excretion rate of Ampicillin which could result in a higher serum level.

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Amrinone Ancec may decrease the informatjon rate of Amrinone which could result in a higher serum level. Anagrelide The therapeutic efficacy of Anagrelide can be decreased when used in combination with Cefazolin. Ancestim Cefazolin may decrease the excretion rate of Ancestim which could result in a higher serum level.

Ancrod The therapeutic efficacy of Ancrod can be infirmation when used in combination with Cefazolin. Anistreplase The therapeutic efficacy of Anistreplase can be decreased when used in combination with Cefazolin. Anthrax immune globulin human The therapeutic efficacy of Anthrax immune globulin human can be decreased when used in combination with Cefazolin. Anthrax vaccine The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Cefazolin.

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Antipyrine The risk or severity of nephrotoxicity can be increased when Cefazolin is combined with Antipyrine. Antithrombin Alfa The therapeutic efficacy of Prescrribing Alfa can be decreased when used in combination with Cefazolin. Antrafenine The risk or severity of nephrotoxicity can be increased when Cefazolin is combined with Antrafenine. Apalutamide Cefazolin may decrease the excretion rate of Apalutamide which could result in a higher serum level.

Apixaban The therapeutic efficacy of Apixaban can be decreased when used in combination with Cefazolin. Apramycin The risk or severity of nephrotoxicity can be increased when Cefazolin is combined with Apramycin. Apremilast Cefazolin may decrease the excretion rate of Apremilast which could result in a higher serum level. Arbekacin The risk or severity of nephrotoxicity can be increased when Cefazolin is combined with Arbekacin. Ardeparin The therapeutic efficacy of Ardeparin can be decreased when used in combination with Cefazolin.

Arformoterol Cefazolin may decrease the excretion rate of Arformoterol which could result in a higher serum level. Argatroban The therapeutic efficacy of Argatroban can be decreased when used in combination with Cefazolin.

Arotinolol Cefazolin may decrease the excretion rate of Arotinolol which could result in a higher serum level. Arsenic trioxide Cefazolin may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.

Aspartame The excretion of Cefazolin can be decreased when combined with Aspartame. Astaxanthin The therapeutic efficacy of Astaxanthin can be decreased when used in combination with Cefazolin.

Ataluren The excretion of Cefazolin can be decreased when combined with Ataluren. Atazanavir The risk or severity of nephrotoxicity can be increased when Atazanavir is combined with Cefazolin. Auranofin Cefazolin may infromation the excretion rate of Auranofin which could result in a higher serum level. Aurothioglucose Cefazolin may decrease the excretion rate of Aurothioglucose which could result in a higher serum level.

Avatrombopag The excretion of Cefazolin can be decreased when combined with Avatrombopag. Avibactam The excretion of Avibactam can be decreased when combined with Cefazolin. Azacitidine Cefazolin may decrease the excretion rate of Azacitidine which could result in a higher serum level. Azapropazone The risk or severity of nephrotoxicity can be increased inforation Cefazolin is combined with Azapropazone.

Azathioprine Cefazolin may decrease the excretion rate of Azathioprine which could result in a higher serum level. Azelaic acid Cefazolin may decrease the excretion rate of Azelaic acid which could result in a higher serum level. Aztreonam Cefazolin may decrease the excretion rate of Aztreonam which could result in a higher serum level.

Ancef – FDA prescribing information, side effects and uses

Bacillus calmette-guerin substrain connaught live antigen The therapeutic efficacy of Bacillus calmette-guerin substrain connaught live antigen can be decreased when used in combination with Cefazolin. Bacillus calmette-guerin substrain danish live antigen The therapeutic efficacy of Bacillus calmette-guerin substrain danish live antigen can be decreased when used in combination with Cefazolin.

Bacillus calmette-guerin substrain tice live inforkation The therapeutic efficacy of Bacillus calmette-guerin substrain tice live antigen can be decreased when used in combination with Cefazolin.