Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Kapvay (clonidine). Concordia Pharmaceuticals Inc.: KAPVAY (clonidine hydrochloride) extended- release is indicated for the treatment of attention deficit. The following text is taken verbatim from the Kapvay package insert: “The dose of Kapvay [ER clonidine], administered either as monotherapy or as adjunctive.
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Clonidine may potentiate the CNS-depressive effects of alcohol, barbiturates or other sedating drugs. There was no drug effects on fertility or on other measures of sexual or neurobehavioral development. Do not take two doses at the same time. If you become pregnant while taking clonidine, call your doctor.
Clonidine: MedlinePlus Drug Information
The cumulative proportion of patients with treatment failure over time during the double-blind phase is displayed in Figure 2. While every effort has been made to assure accurate reproduction, please remember that any visual identification should be considered preliminary. If you suddenly stop taking clonidine, it can cause a rapid rise in your blood pressure and symptoms such as nervousness, headache, and uncontrollable shaking of a part of the body.
Advise patients who have a history of syncope or may have a condition that predisposes them to syncope, such as hypotension, orthostatic hypotension, bradycardia, or dehydration, to avoid becoming dehydrated or overheated [see Warnings and Precautions 5. Ask your doctor or pharmacist for a list of these medicines, if you are not sure if your medicine is listed above.
Your blood pressure should be checked regularly to determine your response to clonidine. Caution is warranted in patients receiving clonidine concomitantly with agents known to affect sinus node function or AV nodal conduction e.
Kapvay | FULL Prescribing Information |
In addition to taking medication, making lifestyle changes will also help to control your blood pressure. Following oral administration of an immediate release formulation, plasma clonidine concentration peaks in insery 3 to 5 hours and the plasma half-life ranges from 12 to 16 hours. Do not drink alcohol or take other medicines that make you sleepy or dizzy while taking KAPVAY until you talk with your doctor.
If your pulse is slower or faster than it should be, call your doctor before taking this medication that day. Continue to take clonidine even if you feel well.
Monitor blood pressure and heart rate, and adjust dosages accordingly in patients treated concomitantly with antihypertensives or other drugs that can reduce blood pressure or heart rate or increase the risk of syncope. What should I know about storage and disposal of this medication? The impact of renal impairment on the pharmacokinetics of clonidine in children has not been assessed.
The chemical name is 2- 2,6-dichlorophenylamino imidazoline hydrochloride. KAPVAY taken with alcohol or medicines that cause sleepiness or dizziness may make your sleepiness or dizziness worse. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Do not take a double dose to make up for a missed one. Information is also available online at https: It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
This is more common when you first start taking clonidine. The dose of KAPVAY, administered either as monotherapy or as adjunctive therapy to a psychostimulant, should be individualized according to the pakcage needs and response of the patient. Clonidine concentrations in plasma increased with increases in dose kapvat the dose range of 0.
Increase daily dosage in increments of 0.
Clonidine stimulates alpha 2 -adrenergic receptors in the brain. The half-life increases up to 41 hours in patients with severe impairment of renal function.
The maximum placebo-subtracted mean change in heart rate was The following is the structural formula: The incidence of “sedation-like” AEs somnolence and fatigue appeared to be independent of clonidine dose or concentration within the studied dose range in the titration study.
Clonidine extended-release long-acting tablets Kapvay are used alone or in combination with other medications as part of a treatment program to control symptoms of attention deficit hyperactivity disorder ADHD; more difficulty focusing, controlling actions, and remaining still or quiet than pckage people who are the same age in children.
All these kapbay in male were not reversed at the end of a 4-week recovery period. Keep this medication in the container it came in, tightly closed, and out of reach of children.
Clonidine hydrochloride is an imidazoline derivative and exists as a mesomeric compound. Why is this medication prescribed?
Immediate-release clonidine hydrochloride and KAPVAY have different pharmacokinetic characteristics; dose substitution on a milligram for milligram basis will result in differences in kapvvay. Treatment Consult with a Certified Poison Control Center for up-to-date guidance and advice.
Clonidine hydrochloride is present in human milk. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol pxckage moderation. Instead, the best way to dispose of your medication is through a medicine take-back program.
Treatments were separated by one-week washout periods. Clonidine treats high blood pressure by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body. The study consisted of a week, open-label phase 4 weeks of dose optimization and 6 weeks of dose maintenancea week double-blind phase, and a 4-week taper-down and follow-up phase. In animal embryofetal studies, increased resorptions were seen in rats and mice administered oral clonidine hydrochloride from implantation through organogenesis at 10 and 5 times, respectively, the maximum recommended human dose MRHD.
KAPVAY clonidine hydrochloride extended-release is a centrally acting alpha 2 -adrenergic agonist available as 0. Your doctor should check your heart rate and blood pressure before starting treatment and regularly during treatment with KAPVAY.
The following serious adverse reactions are described in greater detail elsewhere in labeling:. Your doctor may ask you to check your pulse heart rate daily and will tell you how rapid it should be. Titrate slowly and monitor vital signs frequently.